Summary estimates for each pregnancy outcome at different thresholds in women with pain and/or bleeding with inconclusive ultrasound diagnosis and for women with pain and/or bleeding alone
| Studies (No of participants) | Cut-off (ng/mL) | Sensitivity (95% CI) | Specificity (95% CI) | Positive likelihood ratio (95% CI) | Negative likelihood ratio (95% CI) | Pre-test and post-test probabilities (ranges)* | |||
|---|---|---|---|---|---|---|---|---|---|
| Before test (%) | After test if positive (%) | After test if negative (%) | |||||||
| Women with pain and/or bleeding with inconclusive ultrasound diagnosis | |||||||||
| Progesterone test to predict ectopic v non-ectopic pregnancy: | |||||||||
| 5 studies (1998 women) | <3.2-6 | 36.5 (12 to 70.6) | 41.7 (16 to 72.9) | 0.63 (0.29 to 1.35) | 1.52 (0.99 to 2.36) | 14.2 (7.7-28.6) | 9.44 (5-20.2) | 20.1 (11.3-37.8) | |
| Progesterone test to predict non-viable v viable pregnancy: | |||||||||
| 5 studies (1998 women) | <3.2-6 | 74.6 (50.6 to 89.4) | 98.4 (90.9 to 99.7) | 45.4 (7.13 to 288.9) | 0.26 (0.12 to 0.57) | 73.2 (71.1-85.9) | 99.2 (99.1-99.6) | 44.8 (39-61.3) | |
| Women with pain and/or bleeding alone | |||||||||
| Progesterone test to predict non-viable v viable pregnancy: | |||||||||
| 9 studies (4689 women) | <10 | 66.5 (53.6 to 77.4) | 96.3 (91.1 to 98.5) | 18 (7.19 to 44.8) | 0.35 (0.24 to 0.50) | 62.9 (47.4-71.8) | 96.8 (94.2-97.9) | 37.2 (24-47.1) | |
| 9 studies (5128 women) | <15 | 83.3 (66.6 to 92.6) | 87.5 (78.5 to 93.1) | 6.66 (3.81 to 11.7) | 0.19 (0.09 to 0.40) | 70 (12.6-79.7) | 93.9 (49-96.3) | 30.7 (2.7-42.7) | |
| 8 studies (4348 women) | <20 | 85.7 (72.3 to 93.2) | 66.6 (47.0 to 81.8) | 2.56 (1.46 to 4.50) | 0.22 (0.10 to 0.47) | 61.2 (30.8-71.8) | 80.2 (53.3-86.7) | 25.8 (8.9-35.9) | |
*Pre-test probabilities are median prevalence values with corresponding ranges.