Table 4.
Risk of dementia associated with benzodiazepine use in nested case control study of 1633 elderly people form PAQUID study. Values are numbers (percentages) unless stated otherwise
| Cases | Controls | Odds ratio (95%CI) by drug use | |
|---|---|---|---|
| Ever use analysis | |||
| Univariate analysis*: | (n=467) | (n=1810) | |
| Benzodiazepine non-users | 175 (37) | 845 (46.7) | 1.00 |
| Benzodiazepine ever users | 233 (50) | 741 (40.9) | 1.54 (1.24 to 1.93) |
| Missing exposure | 59 (13) | 224 (12.4) | 1.30 (0.93 to 1.81) |
| Multivariable analysis*†: | (n=449) | (n=1771) | |
| Benzodiazepine non-users | 174 (39) | 844 (47.7) | 1.00 |
| Benzodiazepine ever users | 233 (52) | 738 (41.7) | 1.55 (1.24 to 1.95) |
| Missing exposure | 42 (9) | 189 (10.7) | 1.04 (0.71 to 1.53) |
| Recent/past use analysis | |||
| Univariate analysis*: | (n=467) | (n=1810) | |
| Benzodiazepine non-users | 175 (37) | 845 (46.7) | 1.00 |
| Benzodiazepine recent users | 17 (4) | 52 (2.9) | 1.58 (0.90 to 2.78) |
| Benzodiazepine past users | 216 (46) | 689 (38.1) | 1.54 (1.23 to 1.93) |
| Missing exposure | 59 (13) | 224 (12.4) | 1.30 (0.93 to 1.81) |
| Multivariable analysis*†: | (n=449) | (n=1771) | |
| Benzodiazepine non-users | 174 (39) | 844 (47.7) | 1.00 |
| Benzodiazepine recent users | 17 (4) | 52 (2.9) | 1.48 (0.83 to 2.63) |
| Benzodiazepine past users | 216 (48) | 686 (38.7) | 1.56 (1.23 to 1.98) |
| Missing exposure | 42 (9) | 189 (10.7) | 1.04 (0.71 to 1.53) |
*Matched for age and sex.
†Adjusted for schooling duration, singleness, wine consumption, use of antihypertensive drugs, use of antidiabetic agents, use of statins, use of platelet inhibitors or oral anticoagulants, and significant depressive symptoms according to Center for Epidemiologic Studies depression scale (score ≥17 for men; ≥23 for women), 7 or 8 years before index date.