Table III.
Treg and plasma levels of IL-23, IL-17A, IL-6 and TGF-β1 pre- and post-treatment.
| Chemotherapy | % Trega | IL-23 | IL-17A | IL-6 | TGF-β1 |
|---|---|---|---|---|---|
|
|
|
||||
| median (range) | pg/mlb median (range) | ||||
| GEM (n=15) | |||||
| Time 0c | 4.90 (0.87–16.7) | 34.21 (0–85) | 0 (0–85) | 40.70 (10.68–225.07) | 1691.80 (907.6–5643.5) |
| Time 1d | 2.80 (0.33–7.9) | 24.88 (0–120.24) | 0 (0–6.2) | 17.19 (3.24–160.21) | 1469.80 (690.3–3256.3) |
| p-value | 0.021 | 0.842 | 0.161 | 0.001 | 0.100 |
| GEMOX (n=14) | |||||
| Time 0 | 3.95 (0.57–11.8) | 31.10 (0–103.61) | 0 (0–130.61) | 29.67 (4.54–470.58) | 1502.90 (1127.4–5986.4) |
| Time 1 | 3.6 (0.4–10) | 21.77 (0–80.85) | 0 (0–50.7) | 20.58 (3.24–230.91) | 1855.65(1074.8–3753.3) |
| p-value | 0.638 | 0.059 | 0.046 | 0.088 | 0.683 |
| BEV+CAPE+RT (n=6) | |||||
| Time 0 | 5.10 (0.41–11.3) | 4.15 (0–81.89) | 0 (0–2.07) | 24.08 (20.27–37.62) | 1548.85 (1069.4–3269.2) |
| Time 1 | 6.36 (1.5–13) | 23.32 (0–40.43) | 0 (0–0) | 12.70 (4.54–25.60) | 1964.95 (1056–3134.8) |
| p-value | 0.753 | 0.518 | 0.159 | 0.028 | 0.463 |
a
Percentage of CD4+/CD25+/FoxP3+ cells obtained by flow cytometry;
b
plasma levels measured by ELISA.
c
Pre-chemotherapy;
d
post-chemotherapy (first restaging).