Figure 11.

(A) Extent of neurotoxin-induced bilateral lesions of the LC/SC (n = 10). The rostrocaudal extension was between 0.8 and 1.5 mm, and the LC/SC was always completely destroyed ventrodorsally throughout its rostrocaudal extension. The drawing is simplified from Paxinos and Watson (1998). (B) The effect of either bilateral lesions of the LC/SC (a, n = 10) or sham lesions of the LC/SC (b, n = 10) on the bite latency. Pre, pre-lesions; Post, post-lesions. ^**P < 0.01, significantly different from bite latencies of the non-air-puff condition. Note that a significant air-puff stimulation-induced prolongation of the bite latency was not observed in post-lesions of the LC/SC-lesioned rats, whereas bite latencies were significantly prolonged by air-puff stimulation in pre-lesions, suggesting that the LC/SC is involved in air-puff stimulation-induced nociceptive modulation (Tsuruoka et al., 2011).