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Levels of interleukin 22 in lung tissue samples from rats in the sham operation, severe acute pancreatitis, and melatonin treatment groups. Levels of IL-22 at 1, 4 and 8 h after induction of SAP. Levels of IL-22 decreased with continued progression of SAP (P < 0.01). bP < 0.01 vs the SO group; dP < 0.01 vs the SO and SAP groups (n = 8 rats per group). SO: Sham operation; SAP: Severe acute pancreatitis; IL: Interleukin; Th: T helper cell; MT: Melatonin treatment.
