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Comparison of different tubular segments in mouse kidneys 72 hr after cisplatin treatment. Ultrastructural analysis of COX enzyme activity in proximal vs distal tubules of a cisplatin-treated mouse (Panels A and C). In proximal tubules, activity is clearly decreased (Panel B), while in distal tubules, COX enzyme activity is maintained (Panel D). DT: distal tubule, PT: proximal tubule. Bars in Panels A and C: 2 µm; bars in Panels B and D: 500 nm.
