Figure 6.

“High” (left histogram) and “negative” (right histogram) protein expression profile of vitamin D receptor (VDR), CYP24A1, and CYP27B1 in anaplastic thyroid cancer (ATC) subdivided according to their Ki67 status (low, high) (A) and according to the presence of metastasis (M₀, M₁) at diagnosis (B) and representative photographs of a triple-negative (absent VDR, CYP24A1, and CYP27B1) and triple-positive staining in ATC subdivided according to their Ki67 status (C). (A) More cases of absent VDR, CYP24A1, or CYP27B1 staining were present in ATC cases with a Ki67 “high” status compared with a Ki67 “low” status. (B) Also, more cases of absent VDR, CYP24A1, or CYP27B1 staining were found in ATC M₁ compared with ATC M₀. (C) Representative photographs of two ATC cases with either a triple-positive or a triple-negative staining for VDR, CYP24A1, and CYP27B1 in, respectively the (i) Ki67 low and (ii) Ki67 high ATC subgroup. Scale bar: 50 µm.