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. 2011 Dec;9(4):299–322. doi: 10.2174/187569211798377135

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© 2011 Bentham Science Publishers

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. (1) — Top three pharmacogenomics applications at the nexus of renal pathophysiology and cardiovascular medicine, namely ACE inhibitor treatment, VDR antagonists and moderate dietary salt intake. Arrows represent the direct links as described in the scientific literature. The light blue band across PXR, CAR, VDR and AHR illustrates the tight interplay that exists among these genes. VIP = very important pharmacogenes; SS = genes that are involved in the blood pressure response to salt intake with various levels of evidence.