Table 1.

Interface Between Pharmacogenomics and the Kidney

Context for Research	Focus	Significance
1. Drugs used to treat renal pathologies acting on a protein encoded by a pharmacogene	Drugs	Inter-individual variability in drug response
2. Nephrotoxic drugs	Drugs	Inter-individual variability in nephrotoxicity
3. Proteins involved in the metabolism and transport of drugs and renal function and blood pressure	Endogenous compounds	Inter-individual differences in the progression of chronic kidney disease (even in the absence of drug treatment)
4. Interactions between endogenous and exogenous compounds	Endogenous and exogenous (drugs + others) compounds	Large inter-individual variability in age-related renal function decline