Table 2.

Selected VIP Pharmacogenomics Genes: Renal Function, Blood Pressure and Salt-sensitivity

Gene	Top Three Applications	Level of Evidence Gene Top Three Applications Linking the Gene to:
		Renal Function	Blood Pressure	Salt-sensitivity
ABCB1	Reduced salt intake	+	+	+
ACE	ACE inhibitors, Reduced salt intake	++	++	+
CYP1A2		_	+	_
CYP3A5	Reduced salt intake	+	+	+
MTHFR		+	+	_
PXR		_	(+)	_
VDR	VDR agonists	+	+	_

- No evidence; (+) Indirect evidence; + Direct evidence; ++ Strong evidence.