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. 2012 Aug 9;287(40):33132–33141. doi: 10.1074/jbc.M112.389643

FIGURE 3.

FIGURE 3.

Overexpression of Nedd4-2 eliminates IhERG and decreases hERG 155-kDa expression level. A, effects of Nedd4-2 overexpression on IhERG, IKv1.5, and IEAG. Summarized current amplitudes are shown beneath the respective families of current traces. The numbers in parentheses above each bar indicate the number of cells tested. B, effects of Nedd4-1 and Nedd4-2 overexpression on hERG expression. The relative intensities of hERG bands in cells transfected with Nedd4-1 (n = 4) or Nedd4-2 (n = 7) versus those in control cells are summarized beside the representative Western blot image. **, p < 0.01 versus control (Ctl).