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All components of the HSV-1 replisome form functionally significant species-specific contacts within the replisome. Shown is an autoradiograph from a transient replication experiment using pORI(WT) and expression plasmids encoding either HSV-1 or EHV-1 replication proteins as indicated. The marker is the HindIII-digested p2aori plasmid (36). The autoradiograph is intentionally overexposed to show low levels of replication.
