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. 2012 Aug 7;287(40):33503–33511. doi: 10.1074/jbc.M112.370817

FIGURE 1.

FIGURE 1.

A schematic illustrating the HIV-I HXB2 fusion process and denotes the gp41 extracellular domain. A, HIV fusion cascade. i, naïve state in which gp120 shields gp41. ii, prehairpin intermediate state in which gp120 is attached to its receptor and co-receptor, causing a conformational change. iii, extended prehairpin, in which gp41 is released and the FP is inserted into the host membrane. iv, post-fusion; NHP and CHP formed a six-helix bundle and the fusion progressed. (61). B, a scheme showing the functional regions within the extracellular portion of HIV HXB2 gp41 (amino acids 512–856) (9, 62). CHR, C-terminal heptad repeat; NHR, N-terminal heptad repeat.