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. 2012 Jul 18;287(40):33656–33663. doi: 10.1074/jbc.M112.375154

FIGURE 1.

FIGURE 1.

Capacity of M. tuberculosis strains to induce IL-1β secretion in DCs co-cultured with OT-II CD4+ T cells and to promote Th2 cell differentiation. A, IL-12p40 and IL-1β levels after infection of DCs with H37Rv or BCG. IL-1β levels were significantly increased (p < 0.01) in H37Rv-infected DCs compared with DCs infected with BCG. B, IFN-γ and IL-4 levels after infection of DCs with H37Rv or BCG. IL-4 levels were significantly higher (p < 0.01) in H37Rv-infected DCs than BCG-infected DCs. C, intracellular IFN-γ and IL-4 levels produced by CD4+ T cells from OT-II TCR transgenic mice co-cultured with DCs infected with H37Rv or BCG. The results shown are representative of at least three or four independent experiments. Error bars, ±S.D.