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. 2012 Jul 23;287(40):33675–33690. doi: 10.1074/jbc.M111.325639

FIGURE 3.

FIGURE 3.

Comparison of known structures comprising AT, MCAT, and MAT domains. A, AT52 of Pks13 from M. tuberculosis. B, E. coli MCAT (Protein Data Bank code 2G2Z). C, KS-AT didomain of module 5 from DEBS (Protein Data Bank code 2HG4). D, mammalian FAS-I (Protein Data Bank code 2VZ8). The structures are shown such that the AT domains are in the same orientation. The domains and linkers are color-coded as follows: α/β-hydrolase and ferredoxin-like subdomains, orange and yellow, respectively; KS-AT linkers, cyan; post-AT linkers, red; KS, green; dehydratase (DH), violet; pseudo-methyltransferase (ΨME), blue; pseudo-ketoreductase (ΨKR), magenta; enoyl reductase (ER), lime green; ketoreductase (KR), brown. The second chains of the KS-AT didomain of module 5 from DEBS and mammalian FAS dimers are in light gray.