Table III.
Frequency of SNPs in the patient and control groups
| Variable | Healthy control (n= 93) | ALL (n= 82) | Value of p | |
|---|---|---|---|---|
| T825C exon 8a Value of p for HWE |
C/C | 21 (24.4%) | 24 (32.0%) | 0.409 |
| C/T | 47 (54.7%) | 33 (44.0%) | ||
| T/T | 18 (20.9%) | 18 (24.0%) | ||
| 0.382 | 0.322 | |||
| C3435T exon 26 Value of p for HWE |
C/C | 40 (43.0%) | 39 (47.6%) | 0.775 |
| C/T | 40 (43.0%) | 34 (41.5%) | ||
| T/T | 13 (14.0%) | 9 (11.0%) | ||
| 0.559 | 0.700 | |||
| G2677T exon 21a Value of p for HWE |
A/A | 7 (7.5%) | 5 (6.2%) | 0.630 |
| G/A | 13 (14.0%) | 13 (16.0%) | ||
| G/G | 18 (19.4%) | 14 (17.3%) | ||
| G/T | 28 (30.1%) | 25 (30.9%) | ||
| T/A | 7 (7.5%) | 12 (14.8%) | ||
| T/T | 20 (21.5%) | 12 (14.8%) | ||
| 0.016 | 0.883 | |||
| C1236T exon 12 Value of p for HWE |
C/C | 18 (19.4%) | 16 (19.5%) | 0.289 |
| C/T | 32 (34.4%) | 37 (45.1%) | ||
| T/T | 43 (46.2%) | 29 (35.4%) | ||
| 0.013 | 0.501 | |||
| C421A exon 5 Value of p for HWE |
A/A | 8 (8.6%) | 8 (9.8%) | 0.733 |
| C/A | 42 (45.2%) | 41 (50.0%) | ||
| C/C | 43 (46.2%) | 33 (40.2%) | ||
| 0.614 | 0.353 | |||
| G34A exon 2 Value of p for HWE |
A/A | 11 (11.8%) | 4 (4.9%) | 0.043* |
| G/A | 46 (49.5%) | 32 (39.0%) | ||
| G/G | 36 (38.7%) | 46 (56.1%) | ||
| 0.523 | 0.599 | |||
| C24T exon 1 Value of p for HWE |
T/T | 6 (6.5%) | 3 (3.7%) | 0.418 |
| C/T | 27 (29.0%) | 31 (37.8%) | ||
| C/C | 60 (64.5%) | 48 (58.5%) | ||
| 0.232 | 0.458 | |||
| G1249A exon 10 Value of p for HWE |
A/A | 1 (1.1%) | 2 (2.4%) | 0.823 |
| G/A | 17 (18.3%) | 15 (18.3%) | ||
| G/G | 75 (80.6%) | 65 (79.3%) | ||
| 0.973 | 0.332 | |||
| C3972T exon 28 Value of p for HWE |
T/T | 6 (6.5%) | 3 (3.7%) | 0.141 |
| C/T | 29 (31.2%) | 37 (45.1%) | ||
| C/C | 58 (62.4%) | 42 (51.2%) | ||
| 0.371 | 0.132 |
a
There were 14 values missing (7 for each group) in T825C exon 8, and one value missing in G2677T exon 21 in the patient group.
*
Indicates that a significant association with group was observed for G34A exon 2