Table 4.
In vivo antimalarial efficacy using a single oral dose of 6 mg/kg trioxane and 18 mg/kg mefloquine hydrochloride in P. berghei-infected mice.
| Trioxane | Average survival (days) after infection |
% Suppression of parasitemia (on day 3 post infection) |
|---|---|---|
| 11a | 12.8 (13, 13, 13, 12) | >99.9% |
| 11b | 18.5 (30, 16, 15, 13) | >99.9% |
| 11c | 17.8 (28, 17, 13, 13) | >99.9% |
| 11d | 19.3 (29, 17, 17, 14) | >99.9% |
| 11e | 18.8 (30, 17, 15, 13) | 99.9% |
| 11f | 21.8 (30, 30, 15, 12) | >99.9% |
| 11g | 16.5 (28, 14, 12, 12) | >99.9% |
| 11h | 25.3 (30, 29, 27, 15) | >99.9% |
| 11i | 14.5 (17, 15, 13, 13) | 99.9% |
| 12a | 24.5 (30, 30, 21, 17) | >99.9% |
| 12b | 19.3 (30, 17, 15, 15) | >99.9% |
| 12c | 29.8 (30, 30, 30, 29) | 99.9% |
| 12d | 22.0 (30, 28, 17, 13) | 99.9% |
| 13a | 23.0 (30, 29, 17, 16) | >99.9% |
| 13b | 22.3 (30, 29, 17, 13) | >99.9% |
| 14a | 26.3 (29, 28, 27, 21) | >99.9% |
| 14b | 19.5 (29, 20, 15, 14) | >99.9% |
| 15 | 19.8 (30, 17, 17, 15) | 99.9% |
| Controls | ||
| Infected (no drug) | 8.0 (10, 8, 7, 7) | 0% |
| Artemether + mefloquine-HCl | 16.5 (28, 13, 13, 12) | >99.9% |
| Mefloquine-HCl only | 14.0 (17, 13, 13, 13) | >99.9% |