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. Author manuscript; available in PMC: 2013 Sep 14.
Published in final edited form as: Brain Res. 2012 Aug 2;1473:236–241. doi: 10.1016/j.brainres.2012.07.054

Figure 3.

Figure 3

Mitoxantrone inhibits LPS induction of IL-12 and Il-23 by primary astrocytes. Cells were pre-treated for 1h with the indicated concentration of mitoxantrone. LPS (2 µg/ml) was added as indicated, and 24h later the concentration of IL-12 p40 (A), IL-23 (B), and IL-27 p28 in the culture medium was determined by ELISA. Values represent the mean +/− s.e.m. for triplicate cultures. *p<0.001 vs. LPS treated cultures. Data were analyzed by ANOVA followed by a Bonferroni test to determine the significance of difference. The experiment was performed three times independently.