Table 1.

Overview of clinical (MR- or ultrasound-guided) HIFU liver tumour ablation studies

Authors[Ref.]	Year	Patients (n)	Image guidance	Study design	Study objective
Okada et al.[38]	2006	1	MR-guided	Case report	Feasibility
Visioli et al.[33]	1999	6	Ultrasound-guided	Prospective phase I patient series	Safety and feasibility
Wu et al.[36]	2004	474	Ultrasound-guided	Retrospective patient series	Safety and feasibility
Illing et al.[34]	2005	22	Ultrasound-guided	Prospective patient series	Safety and efficacy
Li et al.[54]	2007	151	Ultrasound-guided	Case-control study	Tumour response and survival
Orsi et al.[52]	2010	23	Ultrasound-guided	Prospective patient series	Safety and efficacy
Jung et al.[55]	2011	79	Ultrasound-guided	Retrospective patient series	Complications
Xu et al.[56]	2011	145	Ultrasound-guided	Prospective patient series	Efficacy and complications
Zhang et al.[57]	2011	27	Ultrasound-guided	Prospective patient series	Imaging response
Jin et al.[58]	2011	73	Ultrasound-guided	Prospective patient series	Long-term follow-up
Fukuda et al.[59]	2011	12	Ultrasound-guided	Prospective patient series	Safety and efficacy