Table 1.

Genes Known to Be Hypomethylated in Common Cancers

Cancer type	Representative hypomethylated genes
Breast	BCSG1, CAV1, CHD1, CDH3, NAT1, UPAN (Jovanovic et al., 2010)
Prostate	PLAU (Pakneshan et al., 2003); TFF1, TFF3 (Vestergaard et al., 2010)
Melanoma	14-3-3σ, GAGE 1–6, HMW-MAA, MAGE-A1, MAGE-A2, MAGE-A3, MAGE-A4, MAGE-A6, NY-ESO-1, PI5, PRAME, SSX 1–5, (Howell et al., 2009)
Pancreatic	CLDN4, LCN2, MSLN, PSCA, S100P, S100A, SERPINB5, SFN, TFF2 (Hong et al., 2011)
Lung	14-3-3σ (Radhakrishnan et al., 2011); C8orf72 (Rauch et al., 2008)
Colorectal	LINE-1 (Sunami et al., 2011); MAEL, SFT2D3 (Kim et al., 2011)