Table 2.
OR adjusted for Age and Study Population, stratified byHeight
|
SNP rs nr |
Genotype |
p-value for interaction |
All individuals |
Height <162.0 cm |
Height 162.0-166.0 cm |
Height >166.0 cm |
||||
|---|---|---|---|---|---|---|---|---|---|---|
| |
|
|
case/contr: 2869/4480 |
case/control: 776/1366 |
case/control: 967/1407 |
case/control: 1023/1502 |
||||
| OR 95%CI | p-trend | OR 95%CI | p-trend | OR 95%CI | p-trend | OR 95%CI | p-trend | |||
| FGFR2 2981582 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.23 (1.10-1.37) |
|
1.35 (1.10-1.66) |
|
1.33 (1.10-1.61) |
|
1.07 (0.89-1.28) |
|
| |
aa |
|
1.48 (1.29-1.69) |
|
1.57 (1.21-2.02) |
|
1.56 (1.22-1.99) |
|
1.32 (1.04-1.67) |
|
| |
Per Allele |
0,41 |
1.22 (1.14-1.30) |
1.34E-08 |
1.26 (1.11-1.43) |
2.86E-04 |
1.26 (1.12-1.42) |
1.65E-04 |
1.14 (1.01-1.28) |
0.03 |
| TNR09 3803662 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.14 (1.03-1.26) |
|
1.09 (0.90-1.32) |
|
1.23 (1.03-1.47) |
|
1.15 (0.97-1.36) |
|
| |
aa |
|
1.39 (1.17-1.67) |
|
1.37 (1.00-1.87) |
|
1.37 (1.00-1.89) |
|
1.42 (1.03-1.95) |
|
| |
Per Allele |
0,91 |
1.16 (1.08-1.25) |
5.34E-05 |
1.14 (1.00-1.31) |
0.06 |
1.20 (1.05-1.37) |
6.78E-03 |
1.17 (1.03-1.33) |
0.02 |
| MAP3K1 889312 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.21 (1.09-1.34) |
|
1.29 (1.06-1.55) |
|
1.14 (0.95-1.36) |
|
1.18 (1.00-1.40) |
|
| |
aa |
|
1.29 (1.09-1.54) |
|
1.31 (0.95-1.81) |
|
1.05 (0.76-1.45) |
|
1.53 (1.14-2.06) |
|
| |
Per Allele |
0,45 |
1.17 (1.08-1.26) |
4.26E-05 |
1.20 (1.04-1.37) |
9.92E-03 |
1.07 (0.94-1.22) |
0.29 |
1.22 (1.07-1.38) |
2.20E-03 |
| 8q24 13281615 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.12 (1.00-1.24) |
|
1.21 (0.98-1.48) |
|
1.07 (0.89-1.29) |
|
1.12 (0.93-1.34) |
|
| |
aa |
|
1.15 (1.00-1.32) |
|
1.24 (0.96-1.60) |
|
1.17 (0.92-1.49) |
|
1.09 (0.87-1.38) |
|
| |
Per Allele |
0,90 |
1.08 (1.01-1.15) |
0.03 |
1.12 (0.99-1.27) |
0.07 |
1.08 (0.96-1.22) |
0.20 |
1.06 (0.94-1.18) |
0.35 |
| LSP1 3817198 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.12 (1.02-1.24) |
|
1.19 (0.99-1.45) |
|
1.08 (0.90-1.28) |
|
1.08 (0.91-1.28) |
|
| |
aa |
|
1.19 (1.00-1.40) |
|
1.50 (1.11-2.02) |
|
1.14 (0.84-1.55) |
|
1.04 (0.79-1.38) |
|
| |
Per Allele |
0,48 |
1.10 (1.02-1.18) |
8.65E-03 |
1.21 (1.06-1.39) |
4.41E-03 |
1.07 (0.94-1.22) |
0.29 |
1.04 (0.92-1.18) |
0.50 |
| 2q35 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.05 (0.93-1.19) |
|
0.90 (0.72-1.14) |
|
1.21 (0.98-1.50) |
|
0.97 (0.79-1.19) |
|
| |
aa |
|
1.20 (1.05-1.37) |
|
1.09 (0.85-1.40) |
|
1.28 (1.01-1.63) |
|
1.21 (0.96-1.52) |
|
| |
Per Allele |
0,38 |
1.10 (1.03-1.17) |
7.47E-03 |
1.05 (0.93-1.19) |
0.43 |
1.13 (1.00-1.27) |
0.04 |
1.10 (0.98-1.23) |
0.11 |
| ESR1 7766585 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.23 (1.10-1.37) |
|
1.12 (0.90-1.38) |
|
1.26 (1.03-1.53) |
|
1.25 (1.04-1.50) |
|
| |
aa |
|
1.02 (0.74-1.41) |
|
0.83 (0.43-1.58) |
|
1.21 (0.69-2.13) |
|
0.98 (0.57-1.66) |
|
| |
Per Allele |
0,83 |
1.16 (1.05-1.27) |
2.66E-03 |
1.05 (0.88-1.26) |
0.60 |
1.20 (1.02-1.42) |
0.03 |
1.16 (0.99-1.36) |
0.06 |
| HCN1 981782 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
0.97 (0.87-1.09) |
|
0.92 (0.74-1.14) |
|
1.03 (0.84-1.26) |
|
1.00 (0.82-1.21) |
|
| |
aa |
|
0.86 (0.75-0.99) |
|
0.91 (0.70-1.18) |
|
0.96 (0.75-1.22) |
|
0.77 (0.61-0.98) |
|
| |
Per Allele |
0,51 |
0.93 (0.87-1.00) |
0.04 |
0.95 (0.83-1.08) |
0.44 |
0.98 (0.87-1.11) |
0.73 |
0.88 (0.78-0.99) |
0.04 |
| ESR1 851987 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
0.91 (0.82-1.02) |
|
0.96 (0.78-1.17) |
|
0.92 (0.76-1.11) |
|
0.87 (0.73-1.05) |
|
| |
aa |
|
0.88 (0.74-1.05) |
|
1.44 (1.06-1.95) |
|
0.69 (0.50-0.96) |
|
0.71 (0.52-0.98) |
|
| Per Allele | 6.70E-03 | 0.93 (0.86-1.00) | 0.06 | 1.12 (0.97-1.28) | 0.12 | 0.86 (0.75-0.99) | 0.04 | 0.86 (0.75-0.98) | 0.02 | |
None of the SNPs showed any tendencies towards significant interactions after stratification according to BMI (Table 3).