Table 3.
OR adjusted for Age and Study Population, stratified byBMI
|
SNP rs nr |
Genotype |
p-value for interaction |
All individuals |
Normal Weigth |
Over Weight |
Obese |
||||
|---|---|---|---|---|---|---|---|---|---|---|
| |
|
|
|
BMI = 18.5-24.99 |
BMI = 25.00-29.99 |
BMI ≥ 30 |
||||
| |
|
|
case/contr: 2869/4480 |
case/control: 1332/2018 |
case/control: 917/1463 |
case/control: 374/619 |
||||
| OR 95%CI | p-trend | OR 95%CI | p-trend | OR 95%CI | p-trend | OR 95%CI | p-trend | |||
| FGFR2 2981582 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.23 (1.10-1.37) |
|
1.26 (1.07-1.48) |
|
1.18 (0.97-1.42) |
|
1.08 (0.80-1.46) |
|
| |
aa |
|
1.48 (1.29-1.69) |
|
1.46 (1.18-1.80) |
|
1.57 (1.24-1.99) |
|
1.14 (0.78-1.66) |
|
| |
Per Allele |
0.59 |
1.22 (1.14-1.30) |
1.34E-08 |
1.21 (1.10-1.35) |
2.03E-04 |
1.25 (1.11-1.40) |
2.20E-04 |
1.07 (0.89-1.29) |
0.49 |
| TNR09 3803662 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.14 (1.03-1.26) |
|
1.16 (1.00-1.35) |
|
1.13 (0.94-1.34) |
|
1.27 (0.97-1.67) |
|
| |
aa |
|
1.39 (1.17-1.67) |
|
1.44 (1.10-1.89) |
|
1.21 (0.89-1.65) |
|
1.72 (1.07-2.78) |
|
| |
Per Allele |
0.72 |
1.16 (1.08-1.25) |
5.34E-05 |
1.18 (1.06-1.32) |
2.88E-03 |
1.11 (0.98-1.26) |
0.11 |
1.30 (1.06-1.58) |
0.01 |
| MAP3K1 889312 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.21 (1.09-1.34) |
|
1.15 (0.99-1.33) |
|
1.33 (1.11-1.58) |
|
1.21 (0.92-1.59) |
|
| |
aa |
|
1.29 (1.09-1.54) |
|
1.22 (0.94-1.59) |
|
1.63 (1.20-2.22) |
|
1.22 (0.76-1.97) |
|
| |
Per Allele |
0.47 |
1.17 (1.08-1.26) |
4.26E-05 |
1.12 (1.01-1.25) |
0.04 |
1.30 (1.14-1.48) |
8.64E-05 |
1.15 (0.94-1.40) |
0.18 |
| 8q24 13281615 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.12 (1.00-1.24) |
|
1.18 (1.01-1.39) |
|
1.04 (0.86-1.25) |
|
1.13 (0.84-1.52) |
|
| |
aa |
|
1.15 (1.00-1.32) |
|
1.22 (0.99-1.49) |
|
1.14 (0.90-1.45) |
|
1.10 (0.75-1.60) |
|
| |
Per Allele |
0.82 |
1.08 (1.01-1.15) |
0.03 |
1.11 (1.01-1.23) |
0.04 |
1.06 (0.95-1.20) |
0.30 |
1.06 (0.88-1.27) |
0.54 |
| LSP1 3817198 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.12 (1.02-1.24) |
|
1.16 (0.99-1.34) |
|
1.11 (0.93-1.33) |
|
0.94 (0.72-1.24) |
|
| |
aa |
|
1.19 (1.00-1.40) |
|
1.41 (1.10-1.81) |
|
1.06 (0.80-1.42) |
|
0.83 (0.50-1.38) |
|
| |
Per Allele |
0.35 |
1.10 (1.02-1.18) |
8.65E-03 |
1.18 (1.06-1.31) |
3.22E-03 |
1.06 (0.93-1.20) |
0.38 |
0.93 (0.75-1.14) |
0.47 |
| 2q35 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.05 (0.93-1.19) |
|
1.04 (0.87-1.24) |
|
1.00 (0.81-1.23) |
|
1.12 (0.80-1.58) |
|
| |
aa |
|
1.20 (1.05-1.37) |
|
1.09 (0.89-1.33) |
|
1.28 (1.01-1.61) |
|
1.38 (0.94-2.03) |
|
| |
Per Allele |
0.63 |
1.10 (1.03-1.17) |
7.47E-03 |
1.04 (0.94-1.15) |
0.40 |
1.13 (1.01-1.27) |
0.04 |
1.18 (0.97-1.43) |
0.09 |
| ESR1 7766585 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.23 (1.10-1.37) |
|
1.29 (1.09-1.52) |
|
1.18 (0.97-1.43) |
|
1.07 (0.79-1.44) |
|
| |
aa |
|
1.02 (0.74-1.41) |
|
0.98 (0.60-1.61) |
|
1.27 (0.76-2.14) |
|
0.51 (0.18-1.41) |
|
| |
Per Allele |
0.47 |
1.16 (1.05-1.27) |
2.66E-03 |
1.19 (1.03-1.37) |
0.02 |
1.16 (0.99-1.37) |
0.07 |
0.96 (0.74-1.24) |
0.75 |
| HCN1 981782 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
0.97 (0.87-1.09) |
|
1.04 (0.87-1.24) |
|
1.01 (0.82-1.23) |
|
0.87 (0.63-1.20) |
|
| |
aa |
|
0.86 (0.75-0.99) |
|
0.84 (0.68-1.04) |
|
1.00 (0.79-1.28) |
|
0.87 (0.59-1.27) |
|
| |
Per Allele |
0.50 |
0.93 (0.87-1.00) |
0.04 |
0.92 (0.83-1.02) |
0.13 |
1.00 (0.89-1.13) |
0.98 |
0.93 (0.77-1.13) |
0.46 |
| ESR1 851987 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
0.91 (0.82-1.02) |
|
0.91 (0.78-1.06) |
|
0.97 (0.80-1.17) |
|
0.92 (0.69-1.22) |
|
| |
aa |
|
0.88 (0.74-1.05) |
|
0.92 (0.71-1.20) |
|
0.83 (0.61-1.13) |
|
0.76 (0.46-1.25) |
|
| Per Allele | 0.89 | 0.93 (0.86-1.00) | 0.06 | 0.94 (0.84-1.05) | 0.29 | 0.93 (0.81-1.07) | 0.30 | 0.89 (0.72-1.10) | 0.28 | |