Table 4.
OR adjusted for Age and Study Population, stratified byHRT
|
SNP rs nr |
Genotype |
p-value for interaction |
All individuals* |
HRT Non Users* |
HRT Current Users* |
HRT Estrogen* |
HRT Comb* |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
|
|
case/contr: 2869/4480 |
case/contr: 1536/2949 |
case/contr: 494/800 |
case/contr: 185/324 |
case/contr:298/455 |
|||||
| OR 95%CI | p-trend | OR 95%CI | p-trend | OR 95%CI | p-trend | OR 95%CI | p-trend | OR 95%CI | p-trend | |||
| FGFR2 2981582 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.23 (1.10-1.37) |
|
1.22 (1.06-1.41) |
|
1.16 (0.89-1.50) |
|
1.15 (0.75-1.75) |
|
1.17 (0.83-1.65) |
|
| |
aa |
|
1.48 (1.29-1.69) |
|
1.55 (1.29-1.89) |
|
1.63 (1.17-2.26) |
|
1.44 (0.86-2.42) |
|
1.87 (1.21-2.89) |
|
| |
Per Allele |
0,83 |
1.22 (1.14-1.30) |
1.34E-08 |
1.24 (1.14-1.36) |
2.04E-06 |
1.26 (1.07-1.49) |
4.83E-03 |
1.20 (0.92-1.55) |
0.18 |
1.34 (1.08-1.66) |
7.30E-03 |
| TNRC9 3803662 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.14 (1.03-1.26) |
|
1.15 (1.01-1.31) |
|
1.17 (0.91-1.49) |
|
1.31 (0.89-1.94) |
|
1.13 (0.83-1.56) |
|
| |
aa |
|
1.39 (1.17-1.67) |
|
1.48 (1.18-1.86) |
|
1.47 (0.96-2.27) |
|
1.56 (0.79-3.11) |
|
1.53 (0.86-2.69) |
|
| |
Per Allele |
0,98 |
1.16 (1.08-1.25) |
5.34E-05 |
1.19 (1.08-1.31) |
3.74E-04 |
1.19 (1.00-1.43) |
0.05 |
1.28 (0.96-1.70) |
0.09 |
1.19 (0.94-1.51) |
0.15 |
| MAP3K1 889312 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.21 (1.09-1.34) |
|
1.27 (1.11-1.45) |
|
1.04 (0.82-1.32) |
|
0.87 (0.59-1.29) |
|
1.13 (0.82-1.54) |
|
| |
aa |
|
1.29 (1.09-1.54) |
|
1.20 (0.95-1.53) |
|
1.54 (1.02-2.33) |
|
1.81 (0.98-3.33) |
|
1.31 (0.74-2.33) |
|
| |
Per Allele |
0,12 |
1.17 (1.08-1.26) |
4.26E-05 |
1.17 (1.06-1.29) |
1.90E-03 |
1.15 (0.97-1.38) |
0.11 |
1.16 (0.88-1.52) |
0.28 |
1.14 (0.90-1.44) |
0.29 |
| 8q24 13281615 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.12 (1.00-1.24) |
|
1.20 (1.04-1.39) |
|
1.05 (0.81-1.34) |
|
0.90 (0.60-1.36) |
|
1.10 (0.80-1.53) |
|
| |
aa |
|
1.15 (1.00-1.32) |
|
1.43 (1.20-1.71) |
|
0.86 (0.61-1.20) |
|
0.88 (0.52-1.51) |
|
0.84 (0.53-1.32) |
|
| |
Per Allele |
0,03 |
1.08 (1.01-1.15) |
0.03 |
1.20 (1.10-1.31) |
6.10E-05 |
0.95 (0.81-1.12) |
0.52 |
0.93 (0.72-1.22) |
0.61 |
0.95 (0.77-1.18) |
0.67 |
| LSP1 3817198 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.12 (1.02-1.24) |
|
1.13 (0.99-1.29) |
|
1.29 (1.01-1.65) |
|
1.32 (0.89-1.94) |
|
1.30 (0.95-1.80) |
|
| |
aa |
|
1.19 (1.00-1.40) |
|
1.06 (0.85-1.31) |
|
1.68 (1.12-2.53) |
|
1.19 (0.61-2.33) |
|
2.35 (1.37-4.03) |
|
| |
Per Allele |
0,13 |
1.10 (1.02-1.18) |
8.65E-03 |
1.06 (0.97-1.17) |
0.21 |
1.30 (1.09-1.55) |
4.07E-03 |
1.18 (0.89-1.56) |
0.26 |
1.44 (1.14-1.82) |
2.16E-03 |
| 2q35 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.05 (0.93-1.19) |
|
1.05 (0.89-1.23) |
|
0.95 (0.72-1.27) |
|
0.77 (0.48-1.25) |
|
1.13 (0.78-1.63) |
|
| |
aa |
|
1.20 (1.05-1.37) |
|
1.15 (0.97-1.38) |
|
1.20 (0.87-1.67) |
|
1.26 (0.75-2.10) |
|
1.20 (0.78-1.85) |
|
| |
Per Allele |
0,68 |
1.10 (1.03-1.17) |
7.47E-03 |
1.08 (0.98-1.17) |
0.11 |
1.10 (0.93-1.29) |
0.26 |
1.14 (0.88-1.48) |
0.33 |
1.10 (0.88-1.36) |
0.40 |
| ESR1 7766585 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
1.23 (1.10-1.37) |
|
1.23 (1.07-1.43) |
|
1.05 (0.81-1.36) |
|
1.31 (0.85-2.03) |
|
0.88 (0.63-1.23) |
|
| |
aa |
|
1.02 (0.74-1.41) |
|
1.01 (0.67-1.53) |
|
1.29 (0.61-2.73) |
|
1.43 (0.52-3.93) |
|
0.86 (0.26-2.81) |
|
| |
Per Allele |
0,47 |
1.16 (1.05-1.27) |
2.66E-03 |
1.15 (1.02-1.31) |
0.02 |
1.07 (0.86-1.34) |
0.53 |
1.26 (0.89-1.79) |
0.19 |
0.89 (0.66-1.21) |
0.46 |
| HCN1 981782 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
0.97 (0.87-1.09) |
|
0.88 (0.76-1.02) |
|
1.15 (0.86-1.53) |
|
0.88 (0.57-1.38) |
|
1.34 (0.92-1.96) |
|
| |
aa |
|
0.86 (0.75-0.99) |
|
0.80 (0.66-0.95) |
|
0.93 (0.66-1.31) |
|
0.74 (0.43-1.28) |
|
1.05 (0.67-1.64) |
|
| |
Per Allele |
0,26 |
0.93 (0.87-1.00) |
0.04 |
0.89 (0.81-0.98) |
0.01 |
0.97 (0.82-1.14) |
0.70 |
0.86 (0.66-1.13) |
0.28 |
1.02 (0.82-1.27) |
0.84 |
| ESR1 851987 |
AA |
|
1 |
|
1 |
|
1 |
|
1 |
|
1 |
|
| |
Aa |
|
0.91 (0.82-1.02) |
|
0.94 (0.82-1.07) |
|
0.80 (0.62-1.04) |
|
0.94 (0.63-1.43) |
|
0.73 (0.52-1.03) |
|
| |
aa |
|
0.88 (0.74-1.05) |
|
0.90 (0.72-1.13) |
|
0.93 (0.62-1.42) |
|
0.88 (0.46-1.68) |
|
0.96 (0.54-1.69) |
|
| Per Allele | 0,52 | 0.93 (0.86-1.00) | 0.06 | 0.94 (0.86-1.04) | 0.24 | 0.90 (0.75-1.09) | 0.28 | 0.94 (0.70-1.25) | 0.67 | 0.87 (0.68-1.12) | 0.29 | |