Table 4.
Association of theACEgene D/I polymorphism, withoutCFTRgenotype distribution and presence ofB. cepacia(BC)
| Group | Ace genotype | Presence | Absence | Total | X2 | p | X2 | p | OR (CI 5-95%) |
|---|---|---|---|---|---|---|---|---|---|
| Without taking CFTR mutation into account |
I/I |
8 |
64 |
72 |
8.654 |
0.013 |
0.468 |
0.498 |
0.699 (0.319 – 1.534) |
| I/D |
9 |
74 |
82 |
0.814 |
0.182 |
0.651 (0.304 – 1.394) |
|||
| D/D |
8 |
16 |
24 |
8,653 |
0.003 |
4.509 (1.513 – 10.89) |
|||
| No identified CFTR mutation |
I/I |
3 |
18 |
21 |
0.530 |
0.767 |
0.003 |
1.29 |
1.056 (0.188 - 5.925) |
| I/D |
2 |
16 |
18 |
0.204 |
1.00 |
0.656 (0.107 - 4.041) |
|||
| D/D |
1 |
3 |
4 |
0.438 |
0.93 |
2.267 (0.196 - 26.27) |
|||
| One CFTR mutation identified class I, II or III |
I/I |
2 |
20 |
22 |
5.539 |
0.063 |
1.248 |
0.466 |
0.383 (0.069 - 2.117) |
| I/D |
2 |
18 |
20 |
0.787 |
0.629 |
0.463 (0.084 - 2.562) |
|||
| D/D |
4 |
5 |
9 |
6.834 |
0.027 |
7.6 (1.43 - 40.38) |
|||
| Two CFTR mutation identified class I, II or III | I/I |
3 |
26 |
29 |
0.511 | 0.774 | 0.084 |
1.07 |
0.8077 (0.193 - 3.387) |
| I/D |
5 |
40 |
45 |
0.039 |
1.10 |
0.875 (0.234 - 3.275) |
|||
| D/D | 2 | 9 | 11 | 0.495 | 0.764 | 1.833 (0.335 - 10.02) |
Values below 0.05 for p denote clinical correlation between variables. OR - odds ratio, CI- confidence interval, D - deleted allele, I - insertion allele. No identified mutation (44 patients) – patients without of identified mutation in classes I, II or III. One identified mutation (51 patients) – patient with one identified mutation in class I, II, or III. Two identified mutation (85 patients) – patient with two mutations in class I, II or III.