Skip to main content
. 2012 Jul 28;2:35. doi: 10.1186/2110-5820-2-35

Table 2.

Pharmacokinetic parameters of selected beta-lactam antibiotics in critically ill patients undergoing CRRT

Antibiotic Patients Dose Renal replacement modalities
 Pharmacokinetic data
RRT Dialyzer QB(mL/min) QUF(mL/min) QDF(mL/h) Cmax(mg/L) tH(h) Vd(l/kg) AUC (mg·h/L) CLtot(mL/min) CLRRT(mL/min) Sc/Sa Ref.
Cefepime
 4
 2 g q8h
 CVVH or CVVHD
 PAN or PS
 140-250
 16.7-35
 500-1000
 100.5 l
 4.6
 0.6
  
 111.5
 27.2
 0.76
 [67]
5
 1-4 g q12h or q24h
 CVVH
 PAN
 150
 16
  
 44.6 - 94.9
 12.9
 0.46
 834.7 -1,677.8
 35.9
 13
 0.86
 [66]
7
 1-4 g q12h or q24h
 CVVHDF
 PAN
 150
 17
 857-1020
 25.7 -90.8
 8.6
 0.34
 344.9 -1,306.8
 46.8
 26
 0.78
8
 2 g q12h
 CVVH or CVVHDF
 AN69
 150
 25.7*
 1610*
 43
 6.17
 0.55
 379
 72.8*
  
  
 [84]
Ceftazidime
 12
 2 g q8h
 CVVH
 PS
 143
 47
  
 58.2
 4.3
 0.52*
 344
 98.7
 32.1
 0.69
 [70]
7
 3 g q24h
 CVVDHF
 AN69
 150
 25
 1000
  
 4
 0.27*
 2514
 62
 33.6
 0.81
 [69]
4
 1-2 g q6h
 CVVH or CVVHDF
 AN69 or PS
 130-140
 25
 500-1000
 53.9-112
 6.4
 0.67
  
 35.5-333.8
 5-65.6
 0.93
 [82]
12
 2 g q12h
 CVVH or CVVHDF
 AN69
 150
 25.7*
 1610*
 78
 7.74
 0.37
 536
 36.4*
  
  
 [84]
Meropenem
 8
 500 mg q12h
 CVVH
 AN69
 10
 26.7
  
 39.5
 3.63
  
 105.3
 82.94
 24.42
 0.91
 [71]
5
 1 g q12h
 CVVH
 AN69
 150
 16.7–33.3
  
  
 5.16
 0.39*
 246
 4.3
 1.96
 0.93
 [86]
5
 1 g q12h
 CVVDHF
 AN69
 150
 16.7 – 25
 1000-1500
10
 1 g q8h
 High volume CVVH
 AN69
 250
 66.7-100
  
 56.6
 4.3
 0.2
 166.5
 100
 58.3
 0.93
 [72]
15
 0.5-1 g q8h or q12h
 CVVHDF
 AN 69
 90-150
 0.17-4.5
 600-1500
  
 5.1
 0.47*
  
 75
 26.7
 0.65
 [87]
5
 0.5 g q12h
 CVVH
 PAN
 200
 25-30
  
 24.5
 6.37
 0.37
 129.5
 4.57
 1.03
 0.63
 [88]
9
 0.5 g q8h or q12h
 CVVH
 AN69
 150-170
 1.7-2.5
  
 38.9
 8.7
 0.17*
  
 52
 22
 1.17
 [72]
9
 1 g Stat
 CVVH
 PS
 150
 45.8
  
 28.1
  
 0.37*
 118
 143.7
 49.7
 0.24
 [89]
Piperacillin/ tazobactam
 6
 4 g q12h/0.5 g q12h
 CVVH
 PS
 100
 13.3
  
  
 7.7/13.9
  
  
 64.8/40.3
  
  
 [90]
CVVHDF
 1000
  
 6.7/11.6
  
  
 84.3/52.2
  
  
  
2000
  
 6.1/9.4
  
  
 91.3/62.5
  
  
8
 2 g/0.25 g or 4 g/0.5 g
 CVVHD
 AN69
 150
 1.3-3.3
 1500
  
 4.3/5.6
 0.31/0.24
  
 47/29.5
 22/17
 0.87/0.64
 [91]
Ceftriaxone
 6
 2-4 g q24h
 CVVH
 PA
 100-150
 20-30
  
  
 10.8
 0.45*
  
  
 16.6
 0.69
 [77]
Flucloxacillin 10 4 g q8h CVVH PA 169 57   139.1-179.7 4.9 0.69* 568 117.2   0.21 [79]

QB, blood flow rate; QUF, ultrafiltration rate; QDF, dialysate flow rate; RRT, renal replacement therapy; Sc, sieving coefficient; Sa, saturation coefficient; Vd, volume of distribution; CL, clearance; Cmax, peak serum concentration; tH, half-life; AUC, area under the concentration vs time curve; CVVH, continuous venovenous hemofiltration; CVVHD, continuous venovenous hemodialysis; CVVHDF, continuous venovenous hemodiafiltration; PAN, polyacrylonitrile; PS, polysulfone; PA, polyamide; *Data were converted considering 70 kg body weight.