Table 1. Estimates of the parameters defining the age-dependent pyrogenic threshold according to study period.

	Baseline period (06/1990–09/1990)	Quinine period (10/1990–12/1994)	Chloroquine period (01/1995–10/2003)	SP+AQ period (11/2003–05/2006)	ACT period (06/2006–07/2008)	ACT+LLINs period (08/2008–12/2010)
Number of individuals	200	386	518	404	479	482
Number of case observations	140	2,689	8,637	1,260	1,134	852
Number of control observations	4,936	8,753	19,653	3,060	5,420	4,525
Exponent for the function of parasitemia ( r )	0.82	0.31	0.37	0.58	0.43	0.72
Age in years of maximum parasitemia ( a )	1	2	2	2	2	2
Maximum threshold parasitemia ( b )	21,500	16,000	14,000	14,000	14,000	10,000
Parasitemia at year 0 ( c )	20,500	15,000	12,000	3,000	2,500	2,500
Lowest threshold parasitemia in adults ( d )	2,000	1,500	1,500	1,000	500	500
Threshold effect odds ratios (95% CI)	33.48 (11.82–94.82)	2.72 (2.11–3.51)	3.01 (2.58–3.53)	2.95 (1.68–5.17)	4.28 (2.55–7.17)	8.49 (1.12–64.08)
Continuous effect of parasitemia odds ratios for an increase of 100 trophozoites/µl (95% CI)	1.04 (1.04–1.05)	1.90 (1.84–1.96)	1.61 (1.59–1.64)	1.18 (1.16–1.20)	1.39 (1.35–1.43)	1.17 (1.12–1.23)
0–1 year old effect odds ratios	1.00	1.00	1.00	1.00	1.00	1.00
2–6 years old effect odds ratios (95% CI)	0.52 (0.28–0.98)	0.73 (0.59–0.90)	1.21 (1.07–1.36)	1.42 (1.05–1.93)	0.62 (0.49–0.79)	1.01 (0.80–1.28)
7–12 years old effect odds ratios (95% CI)	0.24 (0.11–0.49)	0.81 (0.63–1.04)	1.55 (1.33–1.79)	0.66 (0.47–0.91)	0.34 (0.26–0.45)	0.62 (0.46–0.82)
≥13 years old effect odds ratios (95% CI)	0.06 (0.03–0.13)	0.49 (0.39–0.61)	1.05 (0.90–1.22)	0.40 (0.29–0.54)	0.18 (0.14–0.23)	0.36 (0.28–0.46)
AIC	780.55	8476.45	23751.08	3792.72	4516.79	4263.92