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. 2012 Sep 28;7(9):e46188. doi: 10.1371/journal.pone.0046188

Table 2. Number of P. falciparum malaria attacks by treatment period and age according to three definitions of malaria attacks: A. Fever or fever-related symptoms plus parasitemia higher than the period specific threshold level.

Age (in years)
Periods Malaria definitions 0 1 2 3 4–6 7–14 15–29 ≥30 TOTAL (0–14) TOTAL (≥15) TOTAL (All ages)
Quinine A 103 192 244 193 347 267 118 78 1,346 196 1,542
B 88 (−14.6%) 169 (−12.0%) 230 (−5.7%) 183 (−5.2%) 319 (−8.1%) 225 (−15.7%) 99 (−16.1%) 49 (−37.2%) 1,214 (−9.8%) 148 (−24.5%) 1,362 (−11.7%)
C 170 (+65.0%) 278 (+44.8%) 320 (+31.1%) 266 (+37.8%) 595 (+71.5%) 639 (+139.3%) 390 (+230.5%) 221 (+183.3%) 2,268 (+68.5%) 611 (+211.7%) 2,879 (+86.7%)
Chloroquine A 286 476 647 619 1,425 1,169 298 233 4,622 531 5,153
B 231 (−19.2%) 403 (−15.3%) 561 (−13.3%) 535 (−13.6%) 1,134 (−20.4%) 873 (−25.3%) 201 (−32.5%) 124 (−46.8%) 3,737 (−19.1%) 325 (−38.8%) 4,062 (−21.2%)
C 457 (+59.8%) 627 (+31.7%) 841 (+30.0%) 803 (+29.7%) 2,081 (+46.0%) 2,441 (+108.8%) 981 (+229.2%) 693 (+197.4%) 7,250 (+56.9%) 1,674 (+215.2%) 8,924 (+73.2%)
SP+AQ A 27 50 67 80 192 184 34 41 600 75 675
B 19 (−29.6%) 42 (−16.0%) 59 (−11.9%) 67 (−16.2%) 157 (−18.2%) 135 (−26.6%) 21 (−38.2%) 26 (−36.6%) 479 (−20.2%) 47 (−37.3%) 526 (−22.1%)
C 45 (+66.7%) 70 (+40.0%) 83 (+23.9%) 105 (+31.2%) 311 (+62.0%) 384 (+108.7%) 112 (+229.4%) 85 (+107.3%) 998 (+66.3%) 197 (+162.7%) 1,195 (+77.0%)
ACT A 9 19 43 56 150 148 46 36 425 82 507
B 8 (−11.1%) 16 (−15.8%) 41 (−4.6%) 48 (−14.3%) 139 (−7.3%) 115 (−22.3%) 27 (−41.3%) 22 (−38.9%) 367 (−13.6%) 49 (−40.2%) 416 (−17.9%)
C 12 (+33.3%) 35 (+84.2%) 53 (+23.2%) 67 (+19.6%) 192 (+28.0%) 282 (+90.5%) 112 (+143.5%) 70 (+94.4%) 641 (+50.8%) 182 (+121.9%) 823 (+62.3%)
ACT+LLINs A 0 0 5 5 15 39 22 15 64 37 101
B 0 (−0.0%) 0 (−0.0%) 5 (−0.0%) 2 (−60.0%) 13 (−13.3%) 32 (−17.9%) 17 (−22.7%) 13 (−13.3%) 52 (−18.7%) 30 (−18.9%) 82 (−18.8%)
C 1 1 6 (+20.0%) 7 (+40.0%) 19 (+26.7%) 57 (+46.1%) 33 (+50.0%) 21 (+40.0%) 91 (+42.2%) 54 (+45.9%) 145 (+43.6%)

B. Fever or fever-related symptoms plus parasitemia higher than the baseline threshold. C. Fever or fever-related symptoms plus any level of parasitemia. Values in bracket with definition B indicate the proportion of underdiagnosed malaria attacks compared to definition A. Values in bracket with definition C indicate the proportion of overdiagnosed malaria attacks compared to definition A. Dielmo, October 1990–December 2010.