Figure 4. Monitoring tumor growth and body weight of tumor-bearing mice during treatment.

Tumor growth (A) and body weight (B) of tumor-bearing mice treated with saline (as untreated control group), arsenic trioxide (ATO) at 0.5 mg/kg, 2.5 mg/kg or 5.0 mg/kg daily for 12 days. Six mice were used in each group. The tumor volume and body weight of all four groups were also measured every two days. Tumor volume was calculated according to the formula V = (a×b²)/2 where a and b represent the length and width of the tumor. Measurements were continued to 12th day. p<0.05 is a significant difference between control and treatment groups.