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. 2012 Sep 28;7(9):e46615. doi: 10.1371/journal.pone.0046615

Figure 4. Inhibition of all CD4+ T helper lineages is a function of LXR activity.

Figure 4

A, Intracellular cytokine staining on splenocytes differentiated under TH1, TH2, TH17, or iTreg conditions and treated with vehicle (DMSO), T09, GW3965, or SR1001 (5 µM each) for the duration of the time course (4 days). Right: Graphs summarizing the FACS plots. Data was normalized to DMSO controls. B, MTT assays of TH1, TH2, TH17, or iTreg cells cultured with vehicle (D), T09, GW3965, or SR1001 (5 µM each) for the duration of the time course (4 days). Data was normalized to DMSO controls. (n = 4, * p<0.05).