Figure 6. LPA3 mediated LPA effect on the production of PGE2 and on COX-2 expression in the rat uterus during the window of implantation.

Uterine strips from rats pregnant on day 5 of gestation (implantation window) were incubated with LPA 50 µM for 6 h in the presence of DGPP 10 µM (a selective LPA3 antagonist) and the production of PGE2 (A) and the expression of COX-2 mRNA (B) and protein (C) were determined. In A and B: *** p<0,001 vs the rest; In C: ** p<0,01 vs the rest. Results are shown as means ± sem. N = 4–6 for each point. C: control.