Table 4. Effect of LPA and COX inhibitors on the production of PGE2.

	pg PGE2/mg ww
control	8,3±0,4
LPA 50 µM	11,9±1,5a
LPA 50 µM + indomethacin 1 µM	7,5±0,7
LPA 50 µM + NS-398 1 µM	7,4±0,5
indomethacin 1 µM	9,4±0,6
NS-398 1 µM	6,5±1,4

^a:p<0.001 vs the rest.

Uterine strips from rats pregnant on day 5 of gestation were incubated for 6 h with LPA 50 µM alone or in the presence of indomethacin 1 µM (a non selective COX-1 and COX-2 inhibitor) or NS-398 1 µM (a selective COX-2 inhibitor). In another set of experiments, the tissue was incubated for 6 h with indomethacin or NS-398 alone. The production of PGE2 was determined by radioimmunoassay.