Figure 4. Features of translocation breakpoints.

Comparison of average (A) gene content (% bases spanned by transcripts; includes both exons and introns) and (B) chromatin compartment score for Mitelman database translocations (red) and 1,000 permuted sets, each of size n = 571, that preserve the characteristics of the true set. Chromatin compartment scores are calculated using the first eigenvector of the Tanay-normalized correlation matrix (see Methods). Positive and negative scores indicate open and closed chromatin compartments, respectively. (C) Mean Hi-C interaction scores for Mitelman blood translocations (red dots) compared to sets of permuted regions selected from the same chromatin compartments (gray boxplots).