Table 1. Translocation datasets and permutation results.
Dataset | Mean Hi-C Score (Translocations)* | Mean Hi-C Score (Permutations)* | Permutation P-Value | Rank-Sum P-Value | Individual Significant Translocations | Total Unique Translocations | % Genome Covered | % Interactions Covered** | Source |
Mitelman Database | 0.17±0.03 | 0.052±0.001 | <0.001 | 6.42E-23 | 7 | 577 | 79.7% | 1.12% | Mitelman et al. 2011 |
Blood | 0.19±0.03 | 0.063±0.001 | <0.001 | 2.13E-20 | 6 | 440 | 72.4% | 0.87% | |
Non-Blood | 0.10±0.05 | 0.018±0.001 | <0.001 | 1.78E-04 | 1 | 137 | 45.2% | 0.27% | |
Multiple Myeloma | 0.17±0.09 | 0.039±0.002 | <0.001 | 7.27E-03 | 2 | 89 | 22.9% | 0.03% | Chapman et al. 2011 |
Prostate Cancer | 0.07±0.04 | 0.002±0.001 | <0.001 | 7.92E-04 | 0 | 89 | 21.9% | 0.03% | Berger et al. 2011 |
Mendelian | 0.04±0.02 | 0.006±0.001 | <0.001 | 4.05E-03 | 1 | 779 | 91.5% | 0.79% | https://www1.hgu.mrc.ac.uk/Softdata/Translocation/ |
Bounds represent a 95% confidence interval.
Percentage of inter-chromosomal 1-Mb bins that are covered by translocations.