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Sections were obtained from a series of mice sacrificed at various times after ATO (8 mg/kg). Hoechst stain shows reduced perfusion 2–6 hrs following ATO and H&E stain shows increased necrosis after 24 hrs. Left column: vascular extent (CD31; green) and perfusion (Hoechst 33342; blue). Middle column: Caspase-3 activity indicating apoptosis. Right column: H&E.
