Table 1. Inducible depletion of PI(4,5)P2 from plasma membrane inhibits internalization of FMDV and VSV.
% Cells with internalized virions | % Cells without internalizedvirions | P-value | ||
CS8-c1 | Control | 89 | 11 | 0.0001* |
Rapamycin | 12 | 88 | ||
MARLS | Control | 83 | 17 | 0.2202 |
Rapamycin | 76 | 24 | ||
VSV | Control | 88 | 12 | 0.0001* |
Rapamycin | 15 | 85 |
Number of cotransfected cells scored: 100.
Statistically significant difference.