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. 2012 Sep 28;7(9):e46041. doi: 10.1371/journal.pone.0046041

Table 1. Characteristics of the used antigens: all the used antigens were recombinant proteins (from Hoghart et al. [14], modified).

Protein Gene Bank Accession number Remarks Putative function
ESAT-6 Rv3875 6 kDa early secreted antigen Unknown
CFP-10 Rv3874 10 kDa culture filtrate antigen of M. tuberculosis Unknown
Ag85B Rv1886c Secreted antigen, member of the immunodominant complex Antigen 85 Cell wall synthesis, fibronectin binding
PstS1 (38 kDa) Rv0934 Periplasmic phosphate binding protein Protein mediated phosphate transport
TB10.3 Rv3019c Secreted ESAT6-like protein Unknown
HspX (16 kDa;Acr) Rv2031c Heat shock protein. It has been identified as a major protein expressed in dormant state Stress protein induced by anoxia. It has a role in manteinance of long-term viability during latent asymptomatic infection and a proposed role in replication during initial infection
AlaDH Rv2780 Secreted L-alanine deydrogenase of M. tuberculosis May play a role in cell wall synthesis (as L-alanine in an important constituent of the peptidoglycan layer) ; crystal structure varies in the phase of active disease with respect to the state of latent infection in “open” and “closed” ternary forms