Table 3. The most significant genomic regions under selection in MKK using iHS.

Chr	Cluster start position (GRCh37)	Cluster end position (GRCh37)	Genes	Max |iHS| in cluster	# of SNPs in cluster with |iHS| >2
2	134221398	137892309	LCT, MGAT5, NCKAP5, DARS, ZRANB3, R3HDM1, TMEM163, RAB3GAP1, THSD7B, CCNT2, YSK4, UBXN4, MCM6	6.339	545
13	30496779	30565298	–	5.234	26
7	20373632	20468718	ITGB8	5.012	45
2	176089888	176422005	–	4.626	69
11	110532348	110663647	ARHGAP20	4.480	36
9	83127968	83382243	–	4.471	59
5	14657062	14753764	FAM105B, ANKH	4.429	23
18	66652846	66765215	CCDC102B	4.402	33
11	34025053	34189564	CAPRIN1, NAT10, ABTB2	4.375	22
2	179421694	179606538	TTN	4.289	28
14	105792959	105907642	PACS2, MTA1	4.228	20
5	108990708	109217428	MAN2A1	4.219	50
9	107973277	108067684	SLC44A1	4.192	34
9	3869844	3919130	GLIS3	4.185	23
7	99053816	99314986	ZNF789, CPSF4, ATP5J2, FAM200A, ZNF655, ZNF498,CYP3A7, ZKSCAN5, CYP3A5	4.120	24
9	13812037	13867306	–	4.066	23
11	75470813	75678647	UVRAG, DGAT2	4.059	48
2	12294875	12366781	–	4.041	24
14	97426813	97505011	–	4.025	24
8	145839058	146082167	COMMD5, LOC100287170, LOC100129596, ARHGAP39,RPL8, ZNF7, ZNF251, ZNF34, LOC100287297, ZNF517	3.955	22

Using a sliding window of 50 SNPs wide, genomic regions were scored for the fraction of SNPs with |iHS|>2. The top 0.02% of non-overlapping windows were identified and merged into genomic clusters based on genotype R² using the same criterion as in Table 1. Clusters are ranked by the maximum |iHS| value in the cluster. Complete lists of genome-wide significant SNPs and regions identified by iHS are in Tables S2a and S2b respectively.