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OVA: ovalbumin; CNP: Degussa-FW2 (13 nm) carbon nanoparticles; MCH: methacholine; FOT: forced oscillation respiratory mechanics measurements; EELV: end-expiratory lung volume measurements. Brown-Norway rats underwent 4 treatments; OVA-sensitization, CNP tracheal instillation, Both OVA-sensitization and CNP treatment, and sham sensitization and tracheal instillation of vehicle. Equal treatment groups were exposed to either air or NO2.
