Table 1.
ALL | MET copy number | PI3KCA copy number | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Characteristic | N=971 | % | High | Normal/Low | P-value | High | Normal/Lost | P-value | ||||
N=82 | % | N=889 | % | N=134 | % | N=837 | ||||||
Age at Diagnosis | ||||||||||||
Min | 25 | -- | 28 | -- | 25 | -- | 25 | -- | 25 | -- | ||
Median | 53 | -- | 52 | -- | 53.5 | -- | 51 | -- | 54 | -- | ||
Max | 87 | -- | 86 | -- | 87 | -- | 0.3899 | 84 | -- | 87 | -- | 0.0387 |
Tumor size | ||||||||||||
<2cm | 566 | 58.29 | 34 | 41.46 | 532 | 59.84 | 62 | 46.27 | 504 | 60.22 | ||
>=2cm | 369 | 38 | 46 | 56.1 | 323 | 36.33 | 0.0009 | 69 | 51.49 | 300 | 35.84 | 0.0012 |
Nodal Status | ||||||||||||
Positive | 383 | 39.44 | 34 | 41.46 | 349 | 39.26 | 38 | 28.36 | 345 | 41.22 | ||
Negative | 565 | 58.19 | 47 | 57.32 | 518 | 58.27 | 0.8543 | 93 | 69.4 | 472 | 56.39 | 0.0057 |
Grade | ||||||||||||
1 | 92 | 9.47 | 4 | 4.88 | 88 | 9.9 | 5 | 3.73 | 87 | 10.39 | ||
2 | 477 | 49.12 | 35 | 42.68 | 442 | 49.72 | 50 | 37.31 | 427 | 51.02 | ||
3 | 336 | 34.6 | 41 | 50 | 295 | 33.18 | 0.0153 | 72 | 53.73 | 264 | 31.54 | <0.0001 |
Estrogen Receptor | ||||||||||||
Negative | 293 | 30.18 | 38 | 46.34 | 255 | 28.68 | 71 | 52.99 | 222 | 26.52 | ||
Positive | 666 | 68.59 | 44 | 53.66 | 622 | 69.97 | 0.0018 | 62 | 46.27 | 604 | 72.16 | <0.0001 |
Progesterone Receptor | ||||||||||||
Negative | 406 | 41.81 | 42 | 51.22 | 364 | 40.94 | 80 | 59.7 | 326 | 38.95 | ||
Positive | 555 | 57.16 | 40 | 48.78 | 515 | 57.93 | 0.109 | 53 | 39.55 | 502 | 59.98 | <0.0001 |
HER2 | ||||||||||||
Negative | 764 | 78.68 | 68 | 82.93 | 696 | 78.29 | 102 | 76.12 | 662 | 79.09 | ||
Positive | 207 | 21.32 | 14 | 17.07 | 193 | 21.71 | 0.4009 | 32 | 23.88 | 175 | 20.91 | 0.5051 |
Breast Cancer Subtype | ||||||||||||
HER2-positive | 207 | 21.32 | 14 | 17.07 | 193 | 21.71 | 32 | 23.88 | 175 | 20.91 | ||
Hormone receptor-positive | 583 | 60.04 | 44 | 53.66 | 539 | 60.63 | 53 | 39.55 | 530 | 63.32 | ||
Triple receptor negative | 173 | 17.82 | 24 | 29.27 | 149 | 16.76 | 0.0193 | 49 | 36.57 | 124 | 14.81 | <0.0001 |
Menopausal Status | ||||||||||||
Peri/pre-menopausal | 312 | 32.13 | 28 | 34.15 | 284 | 31.95 | 49 | 36.57 | 263 | 31.42 | ||
Post-menopausal | 624 | 64.26 | 52 | 63.41 | 572 | 64.34 | 0.8363 | 80 | 59.7 | 544 | 64.99 | 0.2686 |
Stage | ||||||||||||
I | 304 | 31.31 | 18 | 21.95 | 286 | 32.17 | 32 | 23.88 | 272 | 32.5 | ||
II | 662 | 68.18 | 64 | 78.05 | 598 | 67.27 | 0.0694 | 101 | 75.37 | 561 | 67.03 | 0.0599 |
Histology | ||||||||||||
Ductal | 898 | 92.48 | 78 | 95.12 | 820 | 92.24 | 128 | 95.52 | 770 | 92 | ||
Other | 58 | 5.97 | 3 | 3.66 | 55 | 6.19 | 0.4914 | 2 | 1.49 | 56 | 6.69 | 0.0332 |
MET | ||||||||||||
High copy number | 82 | 8.44 | -- | -- | -- | -- | 21 | 15.67 | 61 | 7.29 | ||
Normal/Low copy number | 889 | 91.56 | -- | -- | -- | -- | -- | 113 | 84.33 | 776 | 92.71 | 0.0021 |
PIK3CA | ||||||||||||
High copy number | 134 | 13.8 | 21 | 25.61 | 113 | 12.71 | -- | -- | -- | -- | ||
Normal/Low copy number | 837 | 86.2 | 61 | 74.39 | 776 | 87.29 | 0.0021 | -- | -- | -- | -- | -- |
Chemotherapy | ||||||||||||
No | 480 | 49.43 | 38 | 46.34 | 442 | 49.72 | 62 | 46.27 | 418 | 49.94 | ||
Anthracycline-based | 323 | 33.26 | 26 | 31.71 | 297 | 33.41 | 49 | 36.57 | 272 | 32.74 | ||
Anthracycline and Taxane-based | 114 | 11.74 | 12 | 14.63 | 102 | 11.47 | 0.6496 | 14 | 10.45 | 100 | 11.95 | 0.5961 |
Radiation Therapy | ||||||||||||
Yes | 410 | 42.22 | 38 | 46.34 | 372 | 41.84 | 47 | 35.07 | 363 | 43.37 | ||
No | 535 | 55.1 | 43 | 52.44 | 492 | 55.34 | 0.5805 | 84 | 62.69 | 451 | 53.88 | 0.0762 |
Endocrine Therapy | ||||||||||||
Yes | 422 | 43.46 | 23 | 28.05 | 399 | 44.88 | 36 | 26.87 | 386 | 46.12 | ||
No | 522 | 53.76 | 58 | 70.73 | 464 | 52.19 | 0.003 | 95 | 70.9 | 427 | 51.02 | <0.0001 |