Table 1.

Patient and Tumor Characteristics

	ALL		MET copy number					PI3KCA copy number
Characteristic	N=971	%	High		Normal/Low		P-value	High		Normal/Lost		P-value
			N=82	%	N=889	%		N=134	%	N=837
Age at Diagnosis
Min	25	--	28	--	25	--		25	--	25	--
Median	53	--	52	--	53.5	--		51	--	54	--
Max	87	--	86	--	87	--	0.3899	84	--	87	--	0.0387
Tumor size
<2cm	566	58.29	34	41.46	532	59.84		62	46.27	504	60.22
>=2cm	369	38	46	56.1	323	36.33	0.0009	69	51.49	300	35.84	0.0012
Nodal Status
Positive	383	39.44	34	41.46	349	39.26		38	28.36	345	41.22
Negative	565	58.19	47	57.32	518	58.27	0.8543	93	69.4	472	56.39	0.0057
Grade
1	92	9.47	4	4.88	88	9.9		5	3.73	87	10.39
2	477	49.12	35	42.68	442	49.72		50	37.31	427	51.02
3	336	34.6	41	50	295	33.18	0.0153	72	53.73	264	31.54	<0.0001
Estrogen Receptor
Negative	293	30.18	38	46.34	255	28.68		71	52.99	222	26.52
Positive	666	68.59	44	53.66	622	69.97	0.0018	62	46.27	604	72.16	<0.0001
Progesterone Receptor
Negative	406	41.81	42	51.22	364	40.94		80	59.7	326	38.95
Positive	555	57.16	40	48.78	515	57.93	0.109	53	39.55	502	59.98	<0.0001
HER2
Negative	764	78.68	68	82.93	696	78.29		102	76.12	662	79.09
Positive	207	21.32	14	17.07	193	21.71	0.4009	32	23.88	175	20.91	0.5051
Breast Cancer Subtype
HER2-positive	207	21.32	14	17.07	193	21.71		32	23.88	175	20.91
Hormone receptor-positive	583	60.04	44	53.66	539	60.63		53	39.55	530	63.32
Triple receptor negative	173	17.82	24	29.27	149	16.76	0.0193	49	36.57	124	14.81	<0.0001
Menopausal Status
Peri/pre-menopausal	312	32.13	28	34.15	284	31.95		49	36.57	263	31.42
Post-menopausal	624	64.26	52	63.41	572	64.34	0.8363	80	59.7	544	64.99	0.2686
Stage
I	304	31.31	18	21.95	286	32.17		32	23.88	272	32.5
II	662	68.18	64	78.05	598	67.27	0.0694	101	75.37	561	67.03	0.0599
Histology
Ductal	898	92.48	78	95.12	820	92.24		128	95.52	770	92
Other	58	5.97	3	3.66	55	6.19	0.4914	2	1.49	56	6.69	0.0332
MET
High copy number	82	8.44	--	--	--	--		21	15.67	61	7.29
Normal/Low copy number	889	91.56	--	--	--	--	--	113	84.33	776	92.71	0.0021
PIK3CA
High copy number	134	13.8	21	25.61	113	12.71		--	--	--	--
Normal/Low copy number	837	86.2	61	74.39	776	87.29	0.0021	--	--	--	--	--
Chemotherapy
No	480	49.43	38	46.34	442	49.72		62	46.27	418	49.94
Anthracycline-based	323	33.26	26	31.71	297	33.41		49	36.57	272	32.74
Anthracycline and Taxane-based	114	11.74	12	14.63	102	11.47	0.6496	14	10.45	100	11.95	0.5961
Radiation Therapy
Yes	410	42.22	38	46.34	372	41.84		47	35.07	363	43.37
No	535	55.1	43	52.44	492	55.34	0.5805	84	62.69	451	53.88	0.0762
Endocrine Therapy
Yes	422	43.46	23	28.05	399	44.88		36	26.87	386	46.12
No	522	53.76	58	70.73	464	52.19	0.003	95	70.9	427	51.02	<0.0001