Table 3.
Multivariate Cox proportional hazard model including MET, PIK3CA copy number and their interaction
| Hazard Ratio | 95% Confidence Intervals | P-value | |
|---|---|---|---|
| All Tumors | |||
| MET Normal/Low copy number | 1 | ||
| MET High Copy number | 1.53 | 0.98-2.38 | 0.06 |
| PIK3CA Normal/Low copy number | 1 | ||
| PIK3CA High Copy number | 1.3 | 0.91-1.86 | 0.147 |
| MET and PIK3CA high copy number | 0.7 | 0.28-1.77 | 0.458 |
| HER2-positive | |||
| MET Normal/Low copy number | 1 | ||
| MET High Copy number | 0.92 | 0.29-2.95 | 0.886 |
| PIK3CA Normal/Low copy number | 1 | ||
| PIK3CA High Copy number | 1.3 | 0.67-2.52 | 0.43 |
| MET and PIK3CA high copy number | 2.68 | 0.4-18.16 | 0.312 |
| Hormone receptor-positive | |||
| MET Normal/Low copy number | 1 | ||
| MET High Copy number | 1.86 | 1.07-3.25 | 0.0287 |
| PIK3CA Normal/Low copy number | 1 | ||
| PIK3CA High Copy number | 1.25 | 0.7-2.23 | 0.4418 |
| MET and PIK3CA high copy number | 0.59 | 0.12-2.89 | 0.515 |
| Triple receptor-negative | |||
| MET Normal/Low copy number | 1 | ||
| MET High copy number | 1.33 | 0.51-3.43 | 0.56 |
| PIK3CA Normal/Low copy number | 1 | ||
| PIK3CA High copy number | 1.17 | 0.6-2.3 | 0.645 |
| MET and PIK3CA high copy number | 0.61 | 0.12-2.95 | 0.535 |