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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Trends Immunol. 2012 Jun 20;33(10):522–530. doi: 10.1016/j.it.2012.05.008

Figure 2. Induction of IFN-β after WNV infection utilizes a different complement of IRF transcription factors in distinct cell types.

Figure 2

In macrophages and mDC, IFN-β is induced at least partially through IPS-1-dependent yet IRF-3 and IRF-7-independent pathways. In macrophages FN-β gene expression utilizes IRF-1 whereas in mDCs another transcription factor (possibly IRF-5) has a complementing role to IRF-3 and IRF-7. The smaller text size in the Figure suggests a subdominant role of these ancillary transcription factors compared to IRF-3 and IRF-7. In comparison, in epithelial cells and fibroblasts loss of IRF-3 and IRF-7 completely ablates IFN-β gene induction after WNV infection.

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