Table 1.

EC₅₀ values of compounds in human TLR8-specific reporter gene assay

Structure	Compound Number	TLR8-Agonistic Activity (μM)
	24	Inactive
	25	Inactive
	26	6.93
	27	10.58
	28	4.91
	29	9.79
	35	Inactive
	36	1.68 Very low AUC
	37a	9.38
	37b	5.81
	37c	Inactive
	37d	9.01 Low AUC
	37e	Inactive
	37f	4.99
	37g	Inactive
	37h	Inactive
	37i	7.64 Low AUC
	37j	Inactive
	37k	Inactive
	37l	Inactive
	37m	4.27 Very low AUC
	37n	Inactive
	38a	2.25 Low AUC
	38b	0.37 Low AUC
	38c	0.85 Low AUC
	39	3.37