. Author manuscript; available in PMC: 2013 Apr 1.

Published in final edited form as: Kidney Int. 2012 Jun 27;82(8):909–919. doi: 10.1038/ki.2012.235

Table 1.

Observed and expected distribution of MPO gene polymorphisms in the primary and replication cohort

Locus	RefSNP number (dbSNP)	Single nucleotide polymorphism	Domain	Number of samples successfully genotyped		Allele frequencies				Hardy Weinberg equilibrium

				Primary cohort	Secondary cohort	Primary cohort		Secondary cohort		Primary cohort		Secondary cohort

						Major	Minor	Major	Minor	χ ²	P value	χ ²	P value
MPO	rs2243828	−765 T to C	Promoter	260	277	T: 0.692	C: 0.308	T: 0.727	C: 0.273	0.22	0.64	0.23	0.63
MPO	rs7208693	157 G to T	Exon 2 (Val53Phe)	262	277	C: 0.874	A: 0.126	C: 0.884	A: 0.116	3.14	0.08	2.51	0.11
MPO	rs2071409	9890 A to C	Intron 11	260	275	A: 0.771	C: 0.229	A: 0.798	C: 0.202	1.41	0.23	2.02	0.16
MPO	rs2759	2149 T to C	Exon 12 (Ile717Val)	259	274	T: 0.932	C: 0.068	T: 0.923	C: 0.077	1.36	0.24	0.27	0.60