Table 4.
Association of the 4 MPO gene polymorphisms with adverse outcomes in the primary cohort
|
MPO gene polymorphism |
Dialysis requirement or in-hospital death |
Dialysis requirement, mechanical ventilation, or in-hospital death |
||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P value | OR | 95% CI | P value | |
| Dominant model | ||||||
| rs2243828 (C-allele vs. T/T) | ||||||
| - Unadjusted | 2.53 | 1.53, 4.19 | <0.001 | 2.31 | 1.40, 3.80 | 0.001 |
| - Model 1 | 2.65 | 1.59, 4.41 | <0.001 | 2.37 | 1.43, 3.92 | 0.001 |
| - Model 2 | 2.19 | 1.25, 3.82 | 0.006 | 2.01 | 1.13, 3.57 | 0.017 |
| - Model 3 | 2.12 | 1.20, 3.75 | 0.010 | 1.98 | 1.10, 3.57 | 0.023 |
| rs7208693 (T-allele vs. G/G) | ||||||
| - Unadjusted | 3.77 | 2.06, 6.92 | <0.001 | 3.79 | 2.02, 7.13 | <0.001 |
| - Model 1 | 4.04 | 2.18, 7.50 | <0.001 | 3.91 | 2.07, 7.38 | <0.001 |
| - Model 2 | 2.73 | 1.38, 5.38 | 0.004 | 2.52 | 1.22, 5.18 | 0.012 |
| - Model 3 | 2.66 | 1.31, 5.41 | 0.007 | 2.54 | 1.19, 5.41 | 0.016 |
| rs2071409 (C-allele vs. A/A) | ||||||
| - Unadjusted | 2.07 | 1.25, 3.43 | 0.005 | 1.65 | 0.99, 2.73 | 0.053 |
| - Model 1 | 2.11 | 1.27, 3.51 | 0.004 | 1.65 | 0.99, 2.73 | 0.054 |
| - Model 2 | 2.09 | 1.18, 3.69 | 0.012 | 1.52 | 0.84, 2.73 | 0.164 |
| - Model 3 | 1.88 | 1.05, 3.38 | 0.035 | 1.34 | 0.73, 2.46 | 0.342 |
| rs2759 (C-allele vs. T/T) | ||||||
| - Unadjusted | 5.63 | 2.36, 13.45 | <0.001 | 5.48 | 2.19, 13.71 | <0.001 |
| - Model 1 | 6.02 | 2.49, 14.55 | <0.001 | 5.71 | 2.26, 14.40 | <0.001 |
| - Model 2 | 3.15 | 1.22, 8.12 | 0.018 | 2.66 | 0.96, 7.37 | 0.059 |
| - Model 3 | 3.13 | 1.17, 8.40 | 0.024 | 2.68 | 0.93, 7.76 | 0.069 |
| Additive model | ||||||
| rs2243828 (per C-allele copy increase) | ||||||
| - Unadjusted | 2.46 | 1.63, 3.72 | <0.001 | 2.22 | 1.48, 3.35 | <0.001 |
| - Model 1 | 2.54 | 1.67, 3.86 | <0.001 | 2.25 | 1.49, 3.41 | <0.001 |
| - Model 2 | 2.13 | 1.35, 3.37 | 0.001 | 1.92 | 1.20, 3.09 | 0.007 |
| - Model 3 | 2.07 | 1.29, 3.33 | 0.003 | 1.89 | 1.15, 3.09 | 0.012 |
| rs7208693(per T-allele copy increase) | ||||||
| - Unadjusted | 3.75 | 2.06, 6.85 | <0.001 | 3.77 | 2.02, 7.05 | <0.001 |
| - Model 1 | 4.02 | 2.17, 7.42 | <0.001 | 3.88 | 2.06, 7.31 | <0.001 |
| - Model 2 | 2.72 | 1.39, 5.35 | 0.004 | 2.51 | 1.22, 5.16 | 0.012 |
| - Model 3 | 2.66 | 1.31, 5.39 | 0.007 | 2.53 | 1.19, 5.39 | 0.016 |
| rs2071409 (per C-allele copy increase) | ||||||
| - Unadjusted | 2.26 | 1.48, 3.45 | <0.001 | 1.87 | 1.23, 2.85 | 0.003 |
| - Model 1 | 2.28 | 1.49, 3.50 | <0.001 | 1.87 | 1.23, 2.85 | 0.004 |
| - Model 2 | 2.26 | 1.40, 3.64 | 0.001 | 1.77 | 1.09, 2.86 | 0.021 |
| - Model 3 | 2.07 | 1.27, 3.37 | 0.004 | 1.59 | 0.97, 2.62 | 0.067 |
| T-G-A-T haplotype * | ||||||
| - Unadjusted | ||||||
| 1 copy (vs. none) | 0.15 | 0.05, 0.40 | <0.001 | 0.18 | 0.07, 0.50 | 0.001 |
| 2 copies (vs. none) | 0.10 | 0.04, 0.30 | <0.001 | 0.14 | 0.05, 0.41 | <0.001 |
| - Model 1 | ||||||
| 1 copy (vs. none) | 0.15 | 0.05, 0.41 | <0.001 | 0.18 | 0.07, 0.51 | 0.001 |
| 2 copies (vs. none) | 0.10 | 0.03, 0.29 | <0.001 | 0.14 | 0.05, 0.40 | <0.001 |
| - Model 2 | ||||||
| 1 copy (vs. none) | 0.16 | 0.06, 0.49 | 0.001 | 0.20 | 0.07, 0.62 | 0.005 |
| 2 copies (vs. none) | 0.13 | 0.04, 0.42 | 0.001 | 0.20 | 0.06, 0.63 | 0.006 |
| - Model 3 | ||||||
| 1 copy (vs. none) | 0.18 | 0.06, 0.55 | 0.003 | 0.22 | 0.07, 0.71 | 0.011 |
| 2 copies (vs. none) | 0.15 | 0.05, 0.50 | 0.002 | 0.23 | 0.07, 0.77 | 0.017 |
95% CI denotes 95% confidence interval for the odds ratio; model 1 is adjusted for sex, race, and age; model 2 is adjusted for sex, race, and APACHE II score; model 3 is adjusted for sex, race, APACHE II score, and plasma MPO level.
*
The haplotype was generated from the MPO rs2243828, rs7208693, rs2071409 and rs2759 polymorphisms.