Table 6.

Association of the 4 MPO gene polymorphisms with > 2-fold increase in serum creatinine, dialysis requirement, prolonged initial mechanical ventilation (>24 hours) or in-hospital death in the secondary cohort

MPO gene polymorphism	Odds ratio	95% CI	P value
Dominant model
rs2243828 (C-allele vs. T/T)
- Unadjusted	1.38	0.68, 2.81	0.375
- Model 1	1.27	0.55, 2.91	0.571
- Model 2	1.20	0.52, 2.78	0.666
rs7208693 (T-allele vs. G/G)
- Unadjusted	1.41	0.64, 3.12	0.395
- Model 1	1.05	0.42, 2.62	0.911
- Model 2	1.14	0.45, 2.87	0.780
rs2071409 (C-allele vs. A/A)
- Unadjusted	2.90	1.41, 5.97	0.004
- Model 1	2.86	1.24, 6.57	0.013
- Model 2	2.82	1.22, 6.50	0.015
rs2759 (C-allele vs. T/T)
- Unadjusted	3.29	1.46, 7.41	0.004
- Model 1	3.50	1.42, 8.58	0.006
- Model 2	3.56	1.44, 8.82	0.006
Additive model
rs2243828 (per C-allele copy increase)
- Unadjusted	1.62	0.94, 2.78	0.082
- Model 1	1.52	0.82, 2.81	0.179
- Model 2	1.47	0.79, 2.74	0.227
rs7208693(per T-allele copy increase)
- Unadjusted	1.36	0.63, 2.94	0.438
- Model 1	1.04	0.42. 2.54	0.939
- Model 2	1.12	0.45, 2.80	0.801
rs2071409 (per C-allele copy increase)
- Unadjusted	2.22	1.30, 3.78	0.003
- Model 1	1.94	1.06, 3.57	0.033
- Model 2	1.91	1.04, 3.51	0.037
T-G-A-T haplotype *
- Unadjusted
1 copy (vs. none)	0.37	0.15, 0.92	0.032
2 copies (vs. none)	0.24	0.08, 0.71	0.010
- Model 1
1 copy (vs. none)	0.46	0.17, 1.27	0.134
2 copies (vs. none)	0.30	0.08, 1.16	0.080
- Model 2
1 copy (vs. none)	0.49	0.18, 1.36	0.173
2 copies (vs. none)	0.32	0.08, 1.28	0.108

95% CI denotes 95% confidence interval for the odds ratio; model 1 is adjusted for age, sex, race and cardiopulmonary bypass time; model 2 is adjusted for age, sex, race, heart failure, surgery status, and cardiopulmonary bypass time.

^*The haplotype was generated from the MPO rs2243828, rs7208693, rs2071409 and rs2759 polymorphisms.