Table 1. Specimen and patient characteristics.
Characteristics of bladder tissue and urine specimens are shown. BGU: patients with benign genitourinary conditions. HX: history of
| Tissue specimens n= 69 (NBL = 25) Organ donors (NBL-O) = 17 BCa patients undergoing cystectomy (NBL-B) = 8 |
Urine Specimens (n = 186) | ||
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| BCa = 44; Transurethral resection (TURBT) = 11 Cystectomy = 33 |
Normal | n = 27 Group 1: n = 17; Age: 38.3 ±13.9; Median: 30.5 yrs Gender: Female = 6; Male = 12 Group 2: n = 10 Age: 63.2 ± 10.1; Median: 61 yrs Gender: Female = 6; Male = 4 |
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| Gender | Female n = 9 Male, n = 35 |
BCa | n = 57 LG = 17; HG = 40 Stage: Ta = 19; CIS = 1; T1 = 15; T2 = 13; T3 = 8; T4 = 1 Age: 68.9 ± 9.2; 69 Gender: Female = 20; Male = 37 |
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| Smoker | +) = 25 (−): 2 Unknown: 17 |
BGU | n = 55 Urinary tract infection = 8 Benign prostatic hyperplasia = 7 Hematuria = 10 Hydronephrosis = 1 Nephrolithiasis = 13 Prostatitis = 5 Hydrocele = 1 Dysuria = 1 Urethral stricture = 4 Impotence = 1 Renal cyst = 3 Adrenal mass = 1 |
| Age = 54.3 ± 12.7; 55 Gender: Female = 23; Male = 32 |
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| Grade | LG = 7 (all, stage Ta) HG = 37 |
HXBCa | n = 30 Age: 65.1 ± 7.6; 63.5 Gender: Female = 7; Male = 23 |
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| HX other cancers | n = 8 Hx Renal cancer n = 2 Hx prostate cancer = 6 Age: 62.9 ± 12.9; 62.5 Gender: Female = 3; Male = 5 |
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| Stage | Ta = 8; T1 = 3 T2 = 12; T3 = 16; T4 = 5 Concomitant CIS was present in 4 patients |
Other cancers | N = 9 Prostate cancer n = 7 Rectal cancer metastatic to bladder = 1 |
| Cervical cancer = 1 Age: 65.7 ± 9.6; 64 Gender: Female = 2; Male = 7 |
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| LN | (+) = 11 (−) = 26 Unknown =7 |
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| Metastasis (all BCa patients) | (−) = 20 (+) = 16 Unknown = 8 |
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| Metastasis in patients with stage ≥ T2 tumor | (−) = 9 (+) = 16 Unknown = 7 |
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| Age | Metastasis (+): 65.7 ± 12.1yrs Median: 68 yrs |
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| Metastasis (−): 64.1 ± 10.9 yrs Median 63 yrs |
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| Neoadjuvant Chemotherapy | (+) = 8 (−) = 24 Unknown = 12 |
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| Adjuvant Chemotherapy | (+) = 6 (−) = 22 Unknown = 16 |
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| Radiation | (+) = 6 (−) = 19 Unknown = 19 |
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| Death | (−) = 23 (+) = 18; BCa specific = 16 Unknown = 3 |
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| Mean Follow-up | 26.8 ± 4.4; median = 20.5 (1* – 120 months) | ||
| For patients with stage ≥ T2 tumor | 19.1 ± 2.2; median = 17.5 (1*–41) | ||
Note:
*
All stage T4 patients were considered as positive for metastasis at the time of diagnosis.