Table 3.
The benefits of metformin in PCOS
| Metabolic/reproductive defects in PCOS | Benefits of metformin | Refs. |
|---|---|---|
| Blood pressure | Reduction | 246 |
| Insulin resistance | Reduction | 252 |
| Fasting insulin | Reduction | 262 |
| New onset of IGT | Reduction | 250, 263 |
| New onset of type 2 DM | Reduction | 250 |
| Fasting triglycerides | Reduction | 262 |
| Fasting cholesterol | +/− | 262 |
| Body weight, BMI, and waist circumference | Reduction | 106, 247–249, 264 |
| Serum androgens | Reduction | 246, 252 |
| Hirsutism scores | No effect | 246, 308 |
| Anovulation | Improvement | 256, 309 |
| Endothelial structure and function | Improvement | 269, 310 |
| IMT | Reduction | 269, 310 |
| Atypical endometrial hyperplasia | Improvement | 24, 270, 311 |