Table 3. Multivariate analysis for overall survival.

	Full model			Reduced model without CRP			Reduced model with CRP
	HR	95% CI	P	HR	Bootstrap-corrected 95% CI	P	HR	Bootstrap-corrected 95% CI	P
Gender: male	0.865	0.603–1.241	0.430
Age	1.023	1.005–1.041	<0.001	1.018	1.002–1.034	0.010	1.021	1.004–1.037	0.004
Poor performance status
(ECOG PS⩾2)	2.038	1.350–3.080	<0.001	3.387	2.283–5.272	<0.001	2.368	1.526–3.943	<0.001
Log (WBC)	1.189	0.7832–1.8061	0.415
Haemoglobin<10 g dl−1	1.519	1.002–2.301	0.049	1.709	1.153–2.613	0.005	1.534	0.928–2.518	0.020
Creatinine	1.036	0.935–1.148	0.500
Albumin: <3 g dl−1	0.863	0.532–1.400	0.550
Log (CRP)	1.600	1.190–2.150	<0.001				1.686	1.267–2.293	<0.001
Log (ALP)	1.281	0.659–2.490	0.465
Log (LDH)	2.340	1.175–4.662	0.016	2.860	1.310–6.472	0.002	2.088	0.879–5.413	0.044
Visceral metastasis	1.362	0.955–1.943	0.018	1.601	1.125–2.385	0.005	1.394	0.955–2.088	0.012
Hydronephrosis	1.100	0.758–1.565	0.644
Primary organ			0.187
Upper urinary tract	0.800	0.569–1.117
Corrected calcium	1.158	0.898–1.493	0.259
Lymph node metastasis	0.621	0.437–0.884	0.008	0.677	0.465–0.998	0.023	0.603	0.399–0.916	0.004
Prior definitive therapy	1.034	0.691–1.546	0.872
Concordance index (original)	(95% CI)			0.765 (0.739–0.792)				0.788 (0.764–0.812)
Concordance index (BOC)				0.761				0.781

Abbreviations: ALP=alkaline phosphatase; BOC=Bootstrap optimism corrected; CRP=C-reactive protein; CI=confidence interval; ECOG PS=Eastern Cooperative Oncology Group Performance Status; HR=hazard ratio; LDH=lactate dehydrogenase; WBC=white blood cell.