Figure 3.

The effect of chemotherapy on activated effector T cells. (A) HLA-DR⁺CD38⁺ effector CD8⁺ T cells from a representative patient, values shown are percentage of total CD8⁺ T cells. (B) The proportion of effector CD8⁺ T cells in all patients during chemotherapy. Graph shows median and interquartile range. Time points were compared using a linear mixed model; ***P<0.001. (C) Bcl-2 expression in HLA-DR⁺CD38⁺ effector CD8⁺ T cells (solid line) vs HLA-DR⁻CD38⁻ naive CD8⁺ T cells (broken line). Shaded area represents the corresponding isotype control.