Fig. 2.

The diagram shows the most studied therapeutic strategies. The therapeutic strategies are ranked by the number of therapeutic approaches that were testing a given strategy. The data table collects the total number of 250 different therapeutic approaches. The most extensively tested strategies are related to the induction of neuroprotection (with neurotrophic factors or by exposing animals to environmental stimuli), mitochondrial dysfunction, or transcriptional deregulation. Interestingly, therapeutic approaches aimed at the specific downregulation of polyQ protein expression are rarely tested in mouse models